Melilotus (sweet clover) is an officinal plant (Melilotus Officinalis) of the Leguminosae family, and has a stem of about eighty centimeters high, dotted with small yellow flowers and pods that make up the fruits. Particularly indicated for the treatment of venous and lymphatic insufficiency, melilotus has a remarkable effect on vessel tone, due to the significant presence of coumarins, as well as possessing anti-inflammatory, diuretic and anti-edematous properties. The coumarins present in melilotus exert a phlebotonic effect, i. e. they are able to increase the venous tone, decrease the permeability of capillaries and increase their resistance. This improves the performance of the blood vessels. The anti-edematous action of coumarins present in melilotus flowers is indicated in association with flavonoids, for those individuals with venous insufficiency. Galen had already included melilotus among the range of therapeutic drugs and its action is particularly beneficial to the eyes in combination with quercetin for disorders of the retina, in particular the macula, resulting from an insufficiently functioning microcirculation.